Spray bottle and tissue

5 Best Enzyme Cleaners in 2022

Why are enzyme cleaners more sought after? Well, simply put, it’s because they get the job done. The enzymes contained in the cleaner are able to break down the dirt and grime and on a biological level to eradicate it. For a pet owner, enzymatic cleaners are a godsend.

They effectively remove urine, all kinds of stains, dirt, grime and pet odors. As a pet parent myself, I can attest to how difficult it is to eliminate messes my fur babies make. Trust me when I say pet enzyme cleaners are worth every penny.

For some reason, pet urine odors seem to linger much longer and seem to be immune to all cleaners except enzymatic ones. We love our pets and want to enjoy their company. One of the only downsides is the mess, but no longer will that be a problem with one of these cleaners.

View The Best Enzyme Cleaners Below

1. Rocco & Roxie Professional Strength Stain & Odor Remover

Rocco & Roxie Professional Strength Stain & Odor Remover

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Treat this mess remover like a miracle cleaner. Whenever you smell or see something unpleasant, just give it a few sprays and – poof! It’s gone! This professional strength cleaner will mow down any mess that stands in its way.

The helpful enzymes will activate when coming in contact with odors and dirt. They endeavor to break down the matter until there is no trace left. It can be used on any surface and furniture!

A dog’s bed and kennel are among the dirtiest of places, just give them a few good sprays here and there. The enzyme stain remover is safe and chlorine-free without leaving any residue behind. If you are not completely satisfied with your purchase, you get your money back in full.

+ Breaks down dirt organically
+ Certified and safe
+ Compatible with any surface
+ 100% satisfaction guarantee

Why We Like It – For tougher stains and odors, let the enzymes do their job by soaking the spot through. You can even spray clothing with stains before putting them in the machine.

2. Simple Solution Extreme Pet Stain and Odor Remover

Simple Solution Extreme Pet Stain and Odor Remover | Enzymatic Cleaner

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If you don’t like the standard cleaner scent, this enzymatic cleaner comes with a scented option. Three times stronger than the average formula, this odor remover cleaner is so strong in fact that it can take out any stain or odor. The enzymes in the ingredients will seep deep into the fabric or material to breakdown any crystals and molecules.

The solution is safe to use around your family members, pets and even children without leaving a residue. To effectively administer the correct amount, Simple Solution has come up with a very simple solution indeed. Their patented nozzle design has three settings: foam, mist, and stream.

+ Includes a scented version
+ Three-times stronger than the average solution
+ Safe to use
+ Three nozzle settings

Why We Like It – This product is made in the USA and complies with all safety standards. Take comfort in knowing you’re keeping a clean house at no risk to your family members or your pet.

3. SIMPLE GREEN Stain and Odor Remover

SIMPLE GREEN Stain and Odor Remover

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Designed especially for dogs, this is a bio-active stain and odor remover that eradicates messes at a biological level. Permanently bid farewell to dirt, odors, urine, feces, etc. Although it does work on most surfaces, it does the job better on porous surfaces such as carpet, tile, and concrete.

This non-toxic and safe formula eliminates messes at the source with the powerful enzymes. It also prevents older stains and odors from lingering and setting in. The effects last longer than other products and the scent isn’t irritating to your nose.

+ Breaks down dirt and odors at the source
+ Contains non-toxic ingredients
+ Powerful enzyme action
+ Pleasant scent

Why We Like It – A cleaner that completely removes new and old stains to prevent your dog from marking the same area, this stain and odor remover does the job right.

4. Emmy’s Best Powerful Pet Odor Remover

Emmy’s Best Powerful Pet Odor Remover

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This Amazon’s Choice product has a triple-action formula. Not only does it remove bothersome stains and odors, but it also prevents repeated soiling of the same area. It gets down to the nitty-gritty and gets rid of all the lingering dirt. A lot of industrial cleaners have an intense smell that isn’t exactly pleasing to the nose.

But Emmy’s Best smells better and than the average product. Replace pungent smells with the fresh scent of calming lavender. To prove their product works and is backed by many positive reviews, Emmy’s Best protects your purchase with a 100% satisfaction guarantee.

+ Triple-action formula
+ Replaces foul smells with lavender
+ 100% satisfaction guarantee
+ Breaks down the dirt at a bacterial level

Why We Liked It – It deters dogs and even cats from repeated soiling of the same area while removing existing odors and dirt.

5. Sunny & Honey Pet Stain & Odor Miracle

Sunny & Honey Pet Stain & Odor Miracle – Enzyme Cleaner for Dogs

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Although this enzyme cleaner is meant for dogs, we know a lot of household messes come from us too. Suitable for many surfaces, this pet stain and odor miracle remover is safe for all members of the family and is effective against all types of stains.

Do your part for all the fur babies in need. Sunny & Honey donates 10% of all profits to animal shelters and animal rescue groups. This stuff is proven to work against the toughest of stains and is also certified by Leaping Bunny.

+ A safe and natural formula
+ Suitable for almost all surfaces
+ Help other dogs in need with your purchase
+ Works against the toughest stains

Why We Like It – Where all other cleaners fail, Sunny & Honey’s miracle formula will prevail. There are so many instances where seemingly permanent stains were removed.

Dog Enzyme Cleaner Buyer’s Guide

Enzymes in cleaners help prompt quicker chemical reactions. The enzymes contained in these miracle cleaners breakdown substances at a biological level, to leave no traces left. A lot of cleaners we use have toxic ingredients in the formula, which could be harmful over a period of time to our family members and fur baby.

Switching to an enzymatic cleaner will keep your loved ones safer, and give yourself an easier time in the face of tough stains. What other key factors should we look for when we buy enzyme cleaners?

What to Look for When Buying Dog Enzyme Cleaners


Look at the label. Most enzyme cleaners should be safe to use with any surface. Some might state they are only suited to fabrics, hardwood or porous material. Try to look for chlorine-free products, as those are safer and won’t bleach your interior.


The ingredients used in all cleaners are different, and in enzyme cleaners as well. While they may all possess helpful enzymes to break down the messes, you need to make sure everything else used is non-toxic. You have a dog at home and chances are children as well, try to look for natural products or organic ones.

Odor eliminating ingredients are also important because they can dissuade your dog from committing the crime again in the same place. Citrus scents are known to be unpleasant for dogs, so lemon-scented or orange-scented cleaners should work well.


How the cleaner is used is also important. Spray bottles are easily administered, and if they have different nozzle settings, it helps you control the amount of cleaner used for different stains. For larger messes, big containers could work better as you need to dilute the solution and scrub out the stain.


Is the cleaner multipurpose? You want to get the most for your money, so finding an enzyme cleaner than can tackle any stain is your best bet. Different surface and different types of stains shouldn’t stand in the way of your cleaner. It should be able to deliver results no matter the mess.


Our fur babies bring us so much joy. However, with joy and affection comes dirt and grime. Your house will never be the same again with the addition of a fur baby. But that shouldn’t get in the way of you getting a dog. The best way to fix this issue is with enzyme cleaners.

They won’t prevent messes, but they sure will take care of them when they appear. We hope our comprehensive guide can help you understand the importance of enzymatic formulas and aid in choosing the right one to fix messes.

Expert Tip

Commercial cleaners can do the job as well, but it requires immediate action. To tell the truth, you might not be home or notice the mess right when it’s made. So instead of living in fear of not catching the next stain, use enzymatic cleaners.

Did You Know

Vinegar and baking soda are natural saviors in stain removal. Baking soda is a renowned ingredient for removing stains on clothes, shoes, and basically anything else. To save on cash, these everyday household items are miracle cleaners in disguise.

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