Best Glucosamine Supplements for Dogs with Joint Pain

10 Best Glucosamine Supplements for Dogs with Joint Pain

Vet Approved Content
  • Sara Redding Ochoa DVM
  • Certified content. This article has been fact checked and verified by our veterinary advisor.

    Approved By: Dr. Sara Ochoa, DVM

Glucosamine: Supplement to Ease Joint Pain in Dogs

Joint supplements are generally of most benefit before any signs of disease in joints are seen, and a typical characteristic of pets is to hide their pain from their owners, I know, it melts my heart too. For this reason, you might not notice your dogs suffering until the problem is quite severe, so the best way to care for your pup’s joint health is through prevention.

Related Review: Benefits and Side Effects of Glucosamine for Dogs

When Should My Dog Start Taking Glucosamine?

The best time to start is when your dog stops growing which is approximately at 10-months for small breeds and 12-18 months for larger breeds though some giant breeds may keep growing up to 2-years of age so you should consult with your vet to decide when is the right time for your pet.

If your pup has passed the growing up stage, don’t fret, it’s better later than never! Glucosamine supplements can be taken later in life with positive effects.

Arthritis Signs in Dogs

Arthritis is a common ailment in pets, as with ourselves with one-in-five dogs suffering from this painful disease. Since our pets hide their suffering, we must monitor their physical health closely as early signs of arthritis are usually subtle at first and may be attributed to your pet aging. Some of the most common symptoms are

– Changes in behavior such as depression, aggression or protectiveness of an area on their body or becoming nervous or anxious

– Reluctance to take part in physical activity or jumping; your pet seeming to be lethargic or lazier than normal

– Difficulty rising from a resting position or apparent stiffness after periods of rest such as in the mornings

– Slowed gait and sometimes limping when walking

– Weight and appetite fluctuations

– Licking particular joints or areas in pain

– Wincing or vocalizing when touched in certain places

– Swelling of a joint, or a limb that is warm or tender to the touch

– Muscle atrophy due to your pet trying to reduce the weight-bearing on a painful leg

– Accidents inside (usually urination)

Best Way to Treat Arthritis in Dogs

Ensure your pet is eating a well-balanced diet appropriate for their life-stage and check with your local veterinary practice about weigh-in clinics to ensure your dog is a healthy weight. Similar to ourselves, obesity in pets puts increased strain on their joints, which will reduce your pet’s quality of life.

Some large breed dog food automatically contains glucosamine and chondroitin since joint issues such as elbow and hip dysplasia are common diseases in these breeds. Senior dog foods may also include these joint supplements to support aging pup’s joints and bones.

Avoid over-doing physical exercise, which put’s even more strain on the already damaged joints in affected pets, and plenty of rest is recommended when pets are suffering from acute bouts of pain. This rest will, of course, be coupled with lots of supportive hugs and kisses!

What are Glucosamine and Chondroitin and How Do They Help My Dog?

Glucosamine is a natural substance found in a healthy dog’s cartilage. This substance helps form and repair body tissues, including cartilage, which is an integral part of joint anatomy. As part of the natural aging process, glucosamine levels decrease in older pets, which can lead to joint pain, stiffness, and eventually arthritis.

Arthritis is joint inflammation, and this occurs when there is ongoing wear and tear happening within joints and cartilage, which has a limited and slow ability to repair itself.

Some studies have shown that glucosamine, chondroitin, and methylsulfonylmethane (MSM) can help the rebuilding process in cartilage. These are encouraging results, and these glucosamine supplements may help reduce pain and restore your pet’s mobility.

If your pup starts taking glucosamine supplements early in life, it may prevent some of these future afflictions. Physical health is directly linked to mental health.

What is the Proper Glucosamine Dosage for Dogs?

When the initial dose of glucosamine is administered, a loading period is required, thus at the start of treatment, the dosage is higher until clinical signs have improved. This ‘loading phase’ is usually about a month, after which the dose may be decreased to a lower amount which can remain at this level throughout the rest of your pet’s life. This is the ‘maintenance phase’ and the generally recommended amount of glucosamine is 20-25mg/lb body weight daily.

You should always consult your vet on the right amount for your specific fur baby and their health situation. The dose varies on breed, size of pet, and severity of the condition your pet is suffering from.

Glucosamine Side Effects to Watch for in Dogs

The most common side effects are gastrointestinal such as vomiting, diarrhea, or constipation and can be minimized or eliminated if you give your pup their glucosamine supplement with food. These symptoms usually reduce over time as with most dietary-induced upset tummies.

Another relatively common side effect of glucosamine supplementation can be allergic reactions, which are for the most part due to an allergy to shellfish, which is often a component in glucosamine and chondroitin supplements. Signs of this reaction are similar to those in humans. Symptoms include hives on the skin, swelling of the face and mouth, itching or even anaphylactic shock.

Anaphylactic shock is VERY rare but if you suspect your pet has an anaphylactic reaction, call your vet immediately for advice while you travel to the nearest veterinary clinic with your pet as this is a severe allergic reaction. Signs of anaphylactic shock include sudden facial swelling and breathing difficulties or choking in your pet. These may also be accompanied by the sudden appearance of hives or a rash on your pet who may be very depressed or distressed. If your pet is allergic to shellfish, there are glucosamine supplements that are produced from corn or other plants which may be a better option for these pets.

Less common side effects:

Fatigue – Your pet may be more tired and lethargic than usual
Insomnia – A pet that is unable to sleep as well as before starting the supplement may be due to glucosamine
Dehydration – Higher doses of glucosamine can cause an increase in thirst and thus urination which may lead to your pet having accidents in the house and needing more water than before, particularly in warm weather

Glucosamine and diabetes – Glucosamine is sugar-based, so if your pup is diabetic, you should consult your veterinarian as this may interfere with sugar levels and how much insulin your pet requires. You and your vet may then be able to decide on suitable dog food for diabetes.

How We Chose the Best Glucosamine for Dogs

Shelf Life

Much of the dog glucosamine supplements will go unused if there is a short shelf life. We made sure that the ones we reviewed didn’t only boost joint health but also keep for a long time.


While pure glucosamine is similar in all products, we tried to look for trusted brands that are also recommended by vets to ensure that your dog gets the best glucosamine supplements without unneeded additives.

Added Chondroitin

Glucosamine and chondroitin both help with joint health, but they may not both be present in the same product. To make sure your pooch gets the maximum protection, we tried to look for ones that do have both.

The Best Glucosamine for Dogs

1. Nutramax Cosequin DS Plus with MSM Chewables

Nutramax Cosequin DS Plus with MSM Chewable Tablets

Product Specifications

  • Brand: Nutramax
  • Lifestage: Adult
  • Breed Size: Small Breeds, Medium Breeds, Large Breeds, Extra Small & Toy Breeds, Giant Breeds, All Breeds
  • Total Weight: 24 pounds
  • Special Diet: Chewable Tablet

Our Review

Nutramax Cosequin DS is a veterinary recommended joint health supplement with an initial loading period of 4-6 weeks. Some dogs, however, may respond sooner than that. Cosequin, another name for glucosamine is coupled with MSM, an organic compound that contains sulfur which helps support your pet’s joints. Nutramax gives your pet the chance to regain or maintain their mobility and a healthy lifestyle.


Glucosamine Hydrochloride (HCl) Minimum 600 mg, Sodium Chondroitin Sulfate Minimum 300 mg, Methylsulfonylmethane (MSM) Minimum 250 mg, Manganese Minimum 3 mg.


+ Vet recommended for joint health
+ Coupled with MSM
+ Safe, effective, good bioavailability
+ Supports cartilage production


– More expensive than some other brands
– Contains some artificial flavors
– May cause some side effects seen in this article

Nutrition Information

Glucosamine Hydrochloride (HCl) Minimum 600 mg
Sodium Chondroitin Sulfate Minimum Minimum 300 mg
Methylsulfonylmethane (MSM) Minimum 250 mg
Manganese Minimum 3 mg.

Why We Like It – The combination of supplements together provides maximum support, which is a significant benefit to the Nutramax Cosequin product. Another is the chewable tablet formula that can easily be mixed with your pet’s food.

2. TerraMax Pro Best Hip and Joint Supplement

TerraMax Pro Best Hip and Joint Supplement

Product Specifications

  • Brand: Terramax
  • Lifestage: Adult, Senior, Puppy
  • Breed Size: Small Breeds, Medium Breeds, Large Breeds, All Breeds
  • Total Weight: Liquid Form
  • Special Diet: No Corn No Wheat No Soy, Gluten Free, Human-Grade

Our Review

TerraMax Pro Hip and Joint Supplement is another veterinary recommended brand, and this 100% pure liquid formula is safe and all-natural! Produced in the USA, using human-grade ingredients, this product gives your pet the maximum joint and hip dysplasia support they deserve.

TerraMax Pro’s formula helps repair and support joint and healthy cartilage function to help your canine best friend regain and maintain their mobility. Alongside these joint benefits, TerraMax can also help with skin and stomach issues.

With a 100% money-back guarantee, you know this is a brand you can trust.


Glucosamine Hcl (Shellfish), Chondroitin Sulfate (Beef And/Or Porcine), MSM (Methyl-Sulfanylmethane 99.9%), Manganese Chelate, Hyaluronic Acid (As Sodium Hyaluronate),100% Pure Aloe Vera Juice, Citric Acid, Potassium Sorbate, Purified Water, Sodium Benzoate, Stevia, Vegetable Glycerin.


+ Liquid formula for better absorption
+ Higher concentration than some other products
+ Easily administered
+ All natural joint health


– May cause some minor side effects as noted above
– Some pets may not like the taste

Nutrition Information

Glucosamine1600 mg
Chondroitin1200 mg
Methylsulfonylmethane (MSM) 1000 mg 
Hyaluronic Acid10 mg

Why We Like It – This liquid form makes it easier to hide the supplement in drinking water or food while ensuring maximal absorption by your pet’s gastrointestinal system.

3. Nutramax Dasuquin with MSM Chewables

Nutramax Dasuquin with MSM Chewables

Product Specifications

  • Brand: Nutramax
  • Lifestage: Adult
  • Breed Size: Large Breeds, Giant Breeds
  • Total Weight: Supplement
  • Special Diet: Chewable Tablet

Our Review

Dasuquin is the number one joint supplement brand recommended by vets across the world. Nutramax claims that this formula aids in healthy cartilage production protect joint cartilage from destruction, and supports healthy joint function. It is one of the most all-round and complete joint support supplements. With more than a decade of clinical use and research behind this brand, it’s paired with MSM to maximize the benefits.


Each Soft Chew Contains: Glucosamine Hydrochloride* 99% (900 mg), Sodium Chondroitin Sulfate* (Low Molecular Weight) (350 mg), Avocado/Soybean Unsaponifiables* (Asu) Powder (90 mg). Dasuquin Chewable Tablets In Formulations Containing MSM (Methylsulfonylmethane). Dasuquin with MSM Contains 400 mg MSM for Small to Medium Dogs and Dasuquin with MSM Contains 800 mg MSM for Large Dogs…


+ Higher concentration than other joint supplements
+ Aids in joint cartilage production
+ Complete support for joint and connective tissues
+ Helps to inhibit the breakdown


– May cause some side effects
– More expensive than other products
– Some pets may not like the taste

Nutrition Information

Glucosamine900 mg
Chondroitin350 mg
Methylsulfonylmethane (MSM) 400 mg 
Avocado/Soybean Unsaponifiables30% min

Why We Like It – Some consumers state that this product is very fast-acting with mobility restored for some pets within 2 weeks to a month allowing you to see visible changes in your pet soon after starting supplementation. For fast relief, you could try Dasuquin from Nutramax.

4. Liquid Health K-9 Glucosamine Hip and Joint Formula

Liquid Health K-9 Glucosamine Hip and Joint Formula

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Product Specifications

  • Lifestage: All stages
  • Breed Size: All breeds
  • Total Weight: Liquid Form
  • Special Diet: Contains no sugar, wheat, gluten, yeast, milk, or soy derivatives

Our Review

This Liquid Health K9 Glucosamine blend combines glucosamine, chondroitin, and MSM to create a powerful formula keeping your pet healthy and happy with flexible and pain-free joints. Produced to support the structural integrity of your dog’s joints, it may even aid in the prevention of arthritis in younger canines. The hyaluronic acid content in this formula helps with lubrication of your pet’s joints.


100% pure aloe vera juice, citric acid, potassium sorbate, purified water, sodium benzoate, vegetable glycerin.


+ Contains USA sourced MSM
+ Easy to administered
+ Easily absorbed
+ Improved joint lubrication


– May cause some side effects
– Some pets may not like the taste

Nutrition Information

Glucosamine1600 mg
Chondroitin Sulfate1200 mg
Methylsulfonylmethane (MSM)1000 mg 
Manganese7 mg
Hyaluronic Acid10 mg

Why We Like It – Your pup could be well on the way to a happier life in as little as 3 weeks! This formula can be mixed with your pet’s water or food making if the perfect choice if your dog is a picky eater or doesn’t like tablets.

5. Zesty Paws Senior Advanced Glucosamine for Dogs

Liquid Health K-9 Glucosamine Hip and Joint Formula

Product Specifications

  • Brand: Zesty Paws 
  • Lifestage: Adult, Senior, Puppy
  • Breed Size: Small Breeds, Medium Breeds, Large Breeds, All Breeds
  • Total Weight: Supplement Chew
  • Special Diet: Grain-Free, No Corn No Wheat No Soy

Our Review

If you’re not just looking for a preventative and your pet is reaching their golden years, then Zesty Paws Senior Advanced Glucosamine for dogs is a great product. A blend of powerful ingredients that promote flexibility and mobility, Zesty Paws gives your aged pup comfort again. These chewable tablets contain glucosamine and chondroitin to help lubricate joints and ease pain in arthritic joints. Natural and organic ingredients are more palatable and better for your pet with added vitamins C and E give your dog’s strength and flexibility a boost and lift their spirits.


Glucosamine HCL: 450 mg, Palm Fruit Oil, Pea Flour, Tapioca Flour, Garbanzo Flour, Flaxseed Meal, Natural Chicken Flavoring, Sunflower Lecithin, Natural Duck Flavoring, Coconut Glycerin, Powdered Cellulose, Rosemary Extract, Mixed Tocopherols, Sorbic Acid (Natural Preservative)…


+ Powerful ingredients to aid aging dogs
+ Lubricates joints
+ Full motion support
+ Tasty flavors


– May cause some side effects mentioned in this article
– May leave yellow stains on a light-colored carpet
– Some picky pets may not like some flavors

Nutrition Information

Glucosamine450 mg
OptiMSM (Methylsulfonylmethane)350 mg
Qmin Curcumin (Curcuma Longa) 200 mg
Green-Lipped Mussel (Perna Canaliculus)200 mg
Chondroitin Sulfate100 mg
Vitamin C (Ascorbic Acid)75 mg
Vitamin E (D-Alpha Tocopherol)32 IU
BioPerine (Piper Nigrum, Fruit)5 mg
Hyaluronic Acid5 mg
Hemp Extract1 mg

Why We Like It – Delicious flavors are inviting to most dogs, and these are easily chewed explicitly formulated for senior dogs. The combination of ingredients gives elderly dogs full joint support.

6. Extend Joint Care for Dogs

Extend Joint Care for Dogs

Product Specifications

  • Brand: Extend
  • Lifestage: Adult, Senior, Puppy
  • Breed Size: Small Breeds, Medium Breeds, Large Breeds, All Breeds
  • Total Weight: Supplement, Food Topping
  • Special Diet: Sprinkle over his food or add a small amount of water to make a rich gravy

Our Review

This joint care supplement is proudly made in the USA, designed to reverse the effects of any joint damage, support joint repair, and maintain joint health. The delicious beef flavor of this powder formula won’t be turned away, even by the pickiest of eaters! An easy way to mix this supplement is to add water, making a gravy to add extra flavor to your pup’s daily meal. Extend Pets offer a 100% money-back guarantee, if you or your pet are not satisfied with the results, your purchase will be refunded with no questions asked. Try the Extend supplement with full confidence if other formulas haven’t worked. It is safe, 100% natural, and veterinarian-formulated!


Active Ingredients: Joint Shield Complex 400mg (Proprietary blend of Glucosamine HCI 300mg, MSM 100mg, Type II Chicken Collagen 100mg, Ascorbic Acid 100mg.


+ Restore your pup’s mobility
+ Tasty beef-flavored
+ Powder form that can be made into gravy or sprinkled on food
+ Supports and helps heal joints


– May cause minor side effects
– Unclear dosing instructions, consult your veterinarian about your pet’s specific requirements

Nutrition Information

Joint Shield Complex 400 mg
(Proprietary blend of Glucosamine HCI 300 mg
MSM100 mg
Type II Chicken Collagen100 mg
Ascorbic Acid 100 mg

Why We Like It – This is an excellent option for pets that don’t accept the chewable or liquid forms. The powder can be an added condiment to their meal when mixed with water to form a gravy paste.

7. VetriScience Laboratories – GlycoFlex 3

VetriScience Laboratories - GlycoFlex 3 Hip and Joint Support for Dogs

Product Specifications

  • Lifestage: Adult, Senior, Puppy
  • Breed Size: Small Breeds, Medium Breeds, Large Breeds, All Breeds
  • Total Weight: Supplement Chew
  • Special Diet: Glucosamine Supplements

Our Review

It always puts our minds at ease when we know veterinarians have recommended a particular brand. This brand has been backed by vets for over 30 years and could help your pet regain up to 41% of his strength and hind leg mobility within 4-weeks of supplementation.

The GlycoFlex 3 formula is clinically proven, and these glucosamine supplements are the company’s 3rd stage of joint care support. VetriScience GlycoFlex 3 is recommended for very active dogs or seniors showing signs of joint pain.


Inactive Ingredients: Brewers Yeast, Canola Oil, Chicken Liver Flavor, Citric Acid, Glycerin, Mixed Tocopherols, Propionic Acid, Proprietary Blend (Maltodextrin, Sodium Alginate and Calcium Sulfate), Rosemary Extract, Silicon Dioxide, Soy Lecithin, Vegetable Oil, Whey (Glycomega Is A Trademark of Aroma New Zealand Ltd.).


+ Clinically tried and tested
+ Veterinarian recommended
+ Two forms, soft chews or tablets


– May cause minor side effects
– Not all dogs may love the flavored

Nutrition Information

Glucosamine HCl (Shrimp and Crab)1,000 mg per (2 chews)
Perna Canaliculus 600 mg
MSM1000 mg
Vitamin E 50 IU
Ascorbic Acid 24 mg

Why We Like It – This is an extra-strength formula specially formulated for dogs that require the maximum joint support. It’s a clinically proven formula offering comprehensive joint support.

8. ProSense Glucosamine for Dogs

ProSense Glucosamine for Dogs, Advanced Hip and Joint Solutions

Product Specifications

  • Brand: ProSense 
  • Lifestage: Adult
  • Breed Size: Small Breeds, Medium Breeds, Large Breeds, All Breeds
  • Total Weight: 1.14 pounds
  • Special Diet: Chewable

Our Review

This advanced formula contains high concentrations of glucosamine to battle more severe cases of joint damage in pets suffering from arthritis and can also be used as a prophylactic. ProSense also adds chondroitin and vitamin C in an easy-to-chew formula that most dogs love.

Pairing the ProSense glucosamine with food or just after a meal will reduce the risks of them having an upset stomach. You can rest easy knowing this has the NASC’s (National Animal Supplement Council) seal of approval, which means it has undergone independent quality checks.


Brewer’s Dried Yeast, Dicalcium Phosphate, Glycerin, Iron Oxide, Magnesium Stearate, Silicon Dioxide, Stearic Acid


+ High concentration of glucosamine
+ Easy to administer chews
+ Advanced strength and support


– May cause some side effects mentioned in this article
– Some pets may not like the flavor

Nutrition Information

Glucosamine HCl650 mg
Chondroitin Sulfate 200 mg
MSM100 mg
Vitamin E 50 IU
Manganese5 mg

Why We Like It – The delicious flavor is almost like offering your pup a treat and may help you to save money on surgery or medication with this advanced formula.

9. Paws & Pals Glucosamine Supplement for Dogs

Paws & Pals Glucosamine Supplement for Dogs

Product Specifications

  • Brand: Paws & Pals 
  • Lifestage: Adult
  • Breed Size: Small Breeds, Medium Breeds, Large Breeds
  • Total Weight: 1.75 pounds
  • Special Diet: Hip and Joint Chewable Supplement

Our Review

Not only is this a joint supplement, Paws & Pals glucosamine supplement also has other benefits due to the added vitamins, minerals, and antioxidants. All these combined ingredients serve to support joints, improve aches and pains, and maintain your pup’s flexibility.

The glucosamine and MSM are anti-inflammatory compounds that may reduce swelling and pain. No longer will your heartbreak as your pup yelps from joint pain.


Glucosamine HCI [Shellfish Source] (500mg), Methylsulfonylmethane [MSM] (500mg), Yucca Schidigera(90mg), Chondroitin Sulfate [Porcine Source] (60mg), Calcium Ascorbate [Vitamin C](58mg), DL-Alpha Tocopheryl Acetate [Vitamin E] (60iu), Omega-3 Fatty Acids (1800mcg), Omega-6 Fatty Acids (946mcg).


+ Extra strength with added ingredients for joint support
+ Helps alleviate pain
+ Maintains cartilage and helps prevent arthritis
+ Made in the USA


– May cause minor side effects like those mentioned in this article
– Not all pets love the flavor

Nutrition Information

Glucosamine HCl500 mg
Chondroitin Sulfate 60 mg
MSM500 mg
Vitamin E 60 IU
Omega-3 Fatty Acids 1800 mcg
Omega-6 Fatty Acids 946mcg

Why We Like It – All the ingredients aim to improve your pet’s overall health. Give the gift of pain-free exercise to your pet and watch them run and jump like their younger selves.

10. Doggie Dailies Glucosamine for Dogs

Doggie Dailies Glucosamine for Dogs

Product Specifications

  • Brand: Doggie Dailies 
  • Lifestage: Adult, Senior
  • Breed Size: Small Breeds, Medium Breeds, Large Breeds, All Breeds
  • Total Weight: 1.2 pounds
  • Special Diet: Hip and Joint Chewable Supplement

Our Review

Doggie Dailies is a company committed to the prevention and alleviation of joint aches and pain in pets. They include two bonus eBooks full of puppy-care tips on how to avoid some common health problems. If for any reason you or your pooch aren’t happy with your purchase, they will refund 100% of your money back.

The Doggie Dailies glucosamine for dogs blends glucosamine, vitamins, minerals, chondroitin, and MSM will target your pup’s mobility issues and help to resolve pain. Try their delicious chicken-flavored chews today.


Inactive Ingredients: Rice Bran, Lecithin, Flaxseed, Rice Flour, Cooked Chicken Powder, Chicken Liver Powder, Mono-and Diglycerides With Citric Acid (To Help Protect Flavor), Molasses, Calcium Carbonate, Egg Powder, Salmon Oil, Cod Liver Oil, Glycerin, Defatted Wheat Germ Flour, Carrot, Crystalline Cellulose, Sorbic Acid (Natural Preservative), Mixed Tocopherols, Rosemary Extract.


+ Delicious chicken flavored
+ Powerful blend of ingredients
+ Safe and certified
+ Made in the USA


– May cause some side effects
– Not all pets will love the flavor
– Contains wheat

Nutrition Information

Glucosamine HCl100 mg (per chew)
Chondroitin Sulfate 50 mg
MSM100 mg
Crude Protein15.0% min
Crude Fat23.0% min
Crude Fiber4.0% max
Moisture9.9% max
Calcium0.8% min

Why We Like It – Bonus gifts are always a plus, and the two eBooks give more insight on how to care for your pooch’s health. This Doggie Dailies blend has other benefits aside from joint care.


We cannot stress this enough; our fur-babies are all unique individuals. Each one has special needs, different genetic make-up, and taste preferences. Nothing can pull at your heartstrings more than seeing your precious pup in pain. While we all understand that patience is a virtue, we don’t often have any when a loved one is in pain. Before you do anything rash, remember to CONSULT YOUR VET FIRST. Only your vet knows best when it comes to your pet, illnesses, and dosing.

Did You Know?

Experts in this field of medicine, together with veterinarians have recently found that the glucosamine produced in your pet’s body is similar to that presented in humans offering many of the same benefits.

Expert Tip

It is recommended to get professional advice and assistance to be on the safe side when it comes to your pooch’s health. For more ways to help a pet with arthritis read this article.

Glucosamine is excellent, but don’t miss out on all the other popular dog supplements available. Be sure to check our probiotics buyer’s guide, our fish oil guide, and our coconut oil guide.

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